Resting brain activity associated with spontaneous fibromyalgia pain
A recent study provides the first direct evidence of linkage between elevated intrinsic (resting-state) brain connectivity and spontaneous pain intensity in patients with fibromyalgia. This research shows an interaction of multiple brain networks, offering greater understanding of how pain arises.
Cell-of-origin for human prostate cancer identified for first time
Scientists have identified for the first time a cell-of-origin for human prostate cancer, a discovery that could result in better predictive and diagnostics tools and the development of new and more effective targeted treatments for the disease.
Fluorescent biosensor to aid in drug development
Scientists have developed a new fluorescent biosensor that could aid in the development of an important class of drugs that target a crucial class of proteins called G protein-coupled receptors (GPCRs). GPCRs are popular drug targets because of the pivotal role they play in cells' communication circuits responsible for regulating functions critical to health, including circuits involved in heart and lung function, mood, cognition and memory, digestion and the inflammatory response.